Design, Synthesis, and Biological Evaluation of Mutual Prodrugs of Some Selected NSAIDs
نویسندگان
چکیده
Non-steroidal Anti-inflammatory drugs (Aceclofenac, Mefenamic acid) have conjugated with different antioxidants such as Thymol, Menthol which having antiulcerogenic activity with the NSAIDsantioxidant mutual prodrug gastro sparing NSAIDs devoid of Ulcerogenic side effects. Two mutual Prodrugs have synthesized in which NSAIDs have been conjugated with different antioxidants by a glycolic acid spacer. The structure was confirmed by using IR, NMR (1H-NMR) & Characterized by some physicochemical properties including the Melting point. Titled compounds showed the significant protection towards inflammation as well as exhibited potential antibacterial activity.
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